Williams C J, Smith R A, Ball R J, Wilkinson H
Department of Paediatrics, York District Hospital.
Arch Dis Child. 1997 Feb;76(2):169-70. doi: 10.1136/adc.76.2.169.
The response to the bisphosphonate, pamidronate, is reported in a child with osteogenesis imperfecta who had recurrent symptomatic hypercalcaemia after immobilisation following fractures. Oral clodronate was effective in the prevention of immobilisation hypercalcaemia in the same child. The bisphosphonates may have other roles in osteogenesis imperfecta by decreasing bone turnover.
据报道，一名成骨不全患儿在骨折后固定期间出现反复症状性高钙血症，对双膦酸盐药物帕米膦酸钠有反应。口服氯膦酸盐对预防该患儿的固定性高钙血症有效。双膦酸盐通过降低骨转换率，在成骨不全中可能还有其他作用。
