Yoshida H, Yoshida T, Iizuka T, Sakakura T, Fujita S
Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Kyoto University, Japan.
Arch Oral Biol. 1996 Nov;41(11):1081-5. doi: 10.1016/s0003-9969(96)00088-x.
In samples of 27 human temporomandibular joints (internal derangement, ankylosis and control specimens) the distribution of immunoreactive tenascin was restricted to the walls of blood vessels, at the perineurium, and at the surface of the disc. Tenascin staining was intense in the stroma of hypertrophic synovial membranes, particularly on the surface of severely hypertrophic synovial membranes with inflammation, proliferation, irregular lining structures and new capillary growth. In situ hybridization of fresh discs and synovial membranes demonstrated that synovial cells as well as fibroblasts and endothelial cells expressed tenascin mRNA. The expression of tenascin mRNA was most evident in synovial cells. It is concluded that synovial cells in the synovial membrane produce tenascin in the diseased human temporomandibular joint.
在27个人类颞下颌关节样本（关节内紊乱、关节强直和对照标本）中，免疫反应性肌腱蛋白的分布局限于血管壁、神经束膜和关节盘表面。在肥厚性滑膜的基质中，肌腱蛋白染色强烈，尤其是在伴有炎症、增殖、不规则衬里结构和新毛细血管生长的严重肥厚性滑膜表面。新鲜关节盘和滑膜的原位杂交显示，滑膜细胞以及成纤维细胞和内皮细胞表达肌腱蛋白mRNA。肌腱蛋白mRNA的表达在滑膜细胞中最为明显。得出的结论是，患病人类颞下颌关节滑膜中的滑膜细胞产生肌腱蛋白。
