Yoshida H, Fujita S, Iizuka T, Yoshida T, Sakakura T
Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Kyoto University, Japan.
Histochem Cell Biol. 1997 Jun;107(6):479-84. doi: 10.1007/s004180050135.
The expression of tenascin (TN) in the tempormandibular joint (TMJ) disc and synovial membrane was examined in 18 human TMJ samples from patients with internal derangement of the TMJ and ten control specimens by an immunohistological technique using paraffin-embedded tissue and specific anti-human TN monoclonal antibody (RCB-1). The expression of TN was observed in all 28 samples, but it was limited to the walls of blood vessels, the perineurium, and the surface of the TMJ disc. The expression of TN was diffuse in the stroma of mildly hypertrophic synovial membranes and focal in the surface of severely hypertrophic synovial membranes. The clinical symptoms of internal derangement of the TMJ are thought to be related to the degree of synovitis. The present study demonstrates that TN is expressed specifically in the portion of the TMJ synovial membrane affected with internal derangement.
采用免疫组织学技术，使用石蜡包埋组织和特异性抗人腱生蛋白单克隆抗体（RCB - 1），对18例颞下颌关节内紊乱患者的颞下颌关节（TMJ）盘和滑膜组织以及10个对照标本进行了腱生蛋白（TN）表达情况的检测。在所有28个样本中均观察到TN的表达，但仅限于血管壁、神经束膜以及TMJ盘表面。TN在轻度肥厚滑膜的基质中呈弥漫性表达，在重度肥厚滑膜表面呈局灶性表达。颞下颌关节内紊乱的临床症状被认为与滑膜炎程度有关。本研究表明，TN在受颞下颌关节内紊乱影响的滑膜部分特异性表达。
