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辐射防护性氨基硫醇对受辐照哺乳动物细胞DNA中单链断裂的诱导和修复的影响。

Effect of radioprotective aminothiols on the induction and repair of single-strand breaks in the DNA of irradiated mammalian cells.

作者信息

Modig H G, Edgren M, Révész L

出版信息

Acta Radiol Ther Phys Biol. 1977 Jun;16(3):245-56. doi: 10.3109/02841867709133944.

DOI:10.3109/02841867709133944
PMID:906893
Abstract

The effect of cysteamine and 2-mercapto-propionyl-glycine on the induction and repair of single-strand breaks in the DNA of Chinese hamster cells by irradiation in vitro in the presence of oxygen or in anoxia was investigated. The substances protected against the formation of breaks by irradiation both under oxic and anoxic conditions. The substances also exhibited a toxic effect which resulted in degradation of DNA. Cysteamine inhibited the rejoining of breaks after radiation exposure.

摘要

研究了半胱胺和2-巯基丙酰甘氨酸对中国仓鼠细胞DNA在有氧或缺氧条件下体外照射诱导的单链断裂及其修复的影响。这些物质在有氧和缺氧条件下均能保护细胞免受辐射诱导的断裂形成。这些物质还表现出毒性作用，导致DNA降解。半胱胺抑制辐射暴露后断裂的重新连接。

相似文献

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Effect of radioprotective aminothiols on the induction and repair of single-strand breaks in the DNA of irradiated mammalian cells.辐射防护性氨基硫醇对受辐照哺乳动物细胞DNA中单链断裂的诱导和修复的影响。
Acta Radiol Ther Phys Biol. 1977 Jun;16(3):245-56. doi: 10.3109/02841867709133944.
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[Effect of cysteamine on repair of individual DNA breaks in an irradiated culture of Chinese hamster cells].[半胱胺对中国仓鼠细胞辐照培养物中单个DNA断裂修复的影响]
Radiobiologiia. 1977 Mar-Apr;17(2):191-5.
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Dual effect of oxygen on the induction and repair of single-strand breaks in the DNA of x-irradiated mammalian cells.氧对受X射线照射的哺乳动物细胞DNA中单链断裂的诱导和修复的双重作用。
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Int J Radiat Biol Relat Stud Phys Chem Med. 1976 Mar;29(3):235-40. doi: 10.1080/09553007614550261.
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Comparative effect of the thiols dithiothreitol, cysteamine and WR-151326 on survival and on the induction of DNA damage in cultured Chinese hamster ovary cells exposed to gamma-radiation.
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Cadmium inhibits repair of UV-, methyl methanesulfonate- and N-methyl-N-nitrosourea-induced DNA damage in Chinese hamster ovary cells.镉抑制中国仓鼠卵巢细胞中紫外线、甲基磺酸甲酯和N-甲基-N-亚硝基脲诱导的DNA损伤的修复。
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Rejoining kinetics of DNA single- and double-strand breaks in normal and DNA ligase-deficient cells after exposure to ultraviolet C and gamma radiation: an evaluation of ligating activities involved in different DNA repair processes.正常细胞和DNA连接酶缺陷细胞在暴露于紫外线C和γ辐射后DNA单链和双链断裂的重新连接动力学：对不同DNA修复过程中涉及的连接活性的评估
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Effects of 3'-deoxyadenosine (cordycepin) on the repair of X-ray-induced DNA single- and double-strand breaks in Chinese hamster V79 cells.3'-脱氧腺苷（虫草素）对中国仓鼠V79细胞中X射线诱导的DNA单链和双链断裂修复的影响。
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Studies on a sulfhydryl radioprotector of low toxicity.低毒性巯基辐射防护剂的研究
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Chem Biol Interact. 1991;79(3):349-58. doi: 10.1016/0009-2797(91)90114-m.

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