Stern L M
Crippled Children's Association of South Australia, Regency Park, South Australia, Australia.
J Paediatr Child Health. 1997 Feb;33(1):52-4. doi: 10.1111/j.1440-1754.1997.tb00991.x.
A study was undertaken to assess the efficacy of an oral anticholinergic drug, glycopyrrolate, in the management of drooling in children and young adults with disabilities.
Glycopyrrolate was used by 24 children and young adults for up to 28 months. Parents/carers were asked to complete a questionnaire on the effects of the drug on severity and frequency of drooling and to report any side-effects.
Twenty-two questionnaires were returned. There was a statistically significant decrease in both severity and frequency of drooling with minimal side-effects reported.
In this preliminary study, glycopyrrolate was found to be an effective and well-tolerated addition to the management of drooling in children with disabilities.
开展一项研究以评估口服抗胆碱能药物格隆溴铵对残疾儿童和青年流涎症的治疗效果。
24名儿童和青年使用格隆溴铵长达28个月。要求家长/护理人员填写一份关于该药物对流涎严重程度和频率影响的问卷，并报告任何副作用。
共收回22份问卷。流涎的严重程度和频率均有统计学意义的降低，且报告的副作用极小。
在这项初步研究中，发现格隆溴铵是治疗残疾儿童流涎症的一种有效且耐受性良好的药物。
