Department of Neurology, Atlanta Veterans Administration Hospital and Emory University School of Medicine, Atlanta, GA, USA.
Neuropsychiatr Dis Treat. 2011;7:543-7. doi: 10.2147/NDT.S14028. Epub 2011 Sep 20.
Excessive drooling may complicate the care of children with chronic neurological conditions by socially isolating both patients and families and by causing secondary dermatitis and infection. Normal control of saliva requires normal integrity of oral structures, normal oropharyngeal sensation, and motor functioning, as well as normal cognitive awareness and rate of salivary production. Glycopyrrolate is an anticholinergic medication with a quaternary structure that recently received Food and Drug Administration approval to treat sialorrhea due to neurological problems in children ages 3-16 years. This review summarizes the few published studies of safety and efficacy of glycopyrrolate for drooling in children with chronic neurological conditions.
流涎过多可通过使患者及其家庭在社交上孤立以及导致继发性皮炎和感染，使慢性神经状况的儿童的护理变得复杂。正常的唾液控制需要口腔结构的正常完整性、正常的口咽感觉和运动功能，以及正常的认知意识和唾液分泌速率。呱仑酸钠是一种具有季铵结构的抗胆碱能药物，最近获得美国食品和药物管理局批准，用于治疗 3-16 岁儿童因神经问题导致的流涎。这篇综述总结了少数已发表的关于呱仑酸钠治疗慢性神经状况儿童流涎的安全性和有效性的研究。
