溶血磷脂酸：G蛋白信号传导与细胞反应。

Lysophosphatidic acid: G-protein signalling and cellular responses.

作者信息

Moolenaar W H, Kranenburg O, Postma F R, Zondag G C

机构信息

Division of Cellular Biochemistry, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 X Amsterdam, The Netherlands.

出版信息

Curr Opin Cell Biol. 1997 Apr;9(2):168-73. doi: 10.1016/s0955-0674(97)80059-2.

DOI:10.1016/s0955-0674(97)80059-2

PMID:9069262

Abstract

Lysophosphatidic acid (LPA) is a serum-borne phospholipid that activates a specific G protein coupled receptor to evoke multiple cellular responses. Recent work has identified two cDNAs encoding putative LPA receptors, various LPA-like agonists that act on distinct receptors, and new pathways that link the receptor(s) to such diverse events as Ras signalling, cytoskeletal remodelling and membrane depolarization.

摘要

溶血磷脂酸（LPA）是一种存在于血清中的磷脂，它能激活特定的G蛋白偶联受体，引发多种细胞反应。最近的研究工作已经鉴定出两个编码假定LPA受体的cDNA、作用于不同受体的各种LPA样激动剂，以及将这些受体与诸如Ras信号传导、细胞骨架重塑和膜去极化等不同事件联系起来的新途径。