Matsumoto K
Second Department of Internal Medicine, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan.
Nephron. 1997;75(3):295-302. doi: 10.1159/000189552.
In this study we have examined the effects of recombinant human interleukin (IL)-13 on peripheral blood monocytes (PBM) from patients with IgA nephropathy (IgAN). Significantly increased spontaneous and lipopolysaccharide (LPS)-stimulated secretion of tumor necrosis factor-alpha (TNF) and IL-8 was determined in PBM cultures of IgAN patients compared to those of normal controls. In the present study, IL-13 inhibited the spontaneous as well as the LPS-stimulated cytokine secretion of PBM in IgAN. Significant inhibitory effect of IL-13 was observed in cultures of PBM from IgAN patients as well as from normal persons. When both LPS and anti-IL-13 antibody were added together to the PBM, a further increase of LPS-enhanced secretion of cytokines occurred. Taken together, these results indicate that IL-13 down-regulates the secretion of TNF and IL-8 from IgAN PBM.
在本研究中，我们检测了重组人白细胞介素（IL）-13对IgA肾病（IgAN）患者外周血单核细胞（PBM）的影响。与正常对照者相比，IgAN患者的PBM培养物中肿瘤坏死因子-α（TNF）和IL-8的自发分泌及脂多糖（LPS）刺激分泌均显著增加。在本研究中，IL-13抑制了IgAN患者PBM的自发及LPS刺激的细胞因子分泌。在IgAN患者以及正常人的PBM培养物中均观察到IL-13的显著抑制作用。当将LPS和抗IL-13抗体一起加入到PBM中时，LPS增强的细胞因子分泌进一步增加。综上所述，这些结果表明IL-13下调了IgAN患者PBM中TNF和IL-8的分泌。
