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2
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本文引用的文献

1
Increased release of tumor necrosis factor-alpha by monocytes from patients with glomerulonephritis.肾小球肾炎患者单核细胞释放肿瘤坏死因子-α增加。
Clin Nephrol. 1993 Sep;40(3):148-54.
2
Production of interleukin 1 in glomerular cell cultures from patients with rapidly progressive crescentic glomerulonephritis.快速进行性新月体性肾小球肾炎患者肾小球细胞培养中白细胞介素1的产生。
Am J Nephrol. 1988;8(6):463-70. doi: 10.1159/000167656.
3
The interleukin 1 gene is expressed by rat glomerular mesangial cells and is augmented in immune complex glomerulonephritis.白细胞介素1基因由大鼠肾小球系膜细胞表达，在免疫复合物性肾小球肾炎中表达增强。
J Immunol. 1987 May 15;138(10):3207-12.
4
Purification and partial biochemical characterization of a human monocyte-derived, neutrophil-activating peptide that lacks interleukin 1 activity.一种缺乏白细胞介素1活性的人单核细胞衍生的中性粒细胞激活肽的纯化及部分生化特性分析
J Immunol. 1987 Nov 15;139(10):3474-83.
5
Production of interleukin-1 by glomerular macrophages in nephrotoxic serum nephritis.肾毒性血清性肾炎中肾小球巨噬细胞白细胞介素-1的产生
Am J Nephrol. 1990;10(6):502-6. doi: 10.1159/000168176.
6
Interleukin-1 beta and tumor necrosis factor-alpha induce gene expression and production of leukocyte chemotactic factors, colony-stimulating factors, and interleukin-6 in human mesangial cells.白细胞介素-1β和肿瘤坏死因子-α可诱导人系膜细胞中白细胞趋化因子、集落刺激因子和白细胞介素-6的基因表达及产生。
Am J Pathol. 1991 Apr;138(4):991-1003.
7
Cytokine-activated human mesangial cells generate the neutrophil chemoattractant, interleukin 8.细胞因子激活的人系膜细胞产生中性粒细胞趋化因子白细胞介素8。
Kidney Int. 1991 Jul;40(1):86-90. doi: 10.1038/ki.1991.184.
8
Cytokine- and LPS-induced synthesis of interleukin-8 from human mesangial cells.细胞因子和脂多糖诱导人系膜细胞合成白细胞介素-8。
Kidney Int. 1991 Jun;39(6):1240-8. doi: 10.1038/ki.1991.157.
9
Interleukin-1 production by monocytes from patients with glomerulonephritis after stimulation in vitro with soluble immune complexes.肾小球肾炎患者的单核细胞在体外用可溶性免疫复合物刺激后白细胞介素-1的产生。
Clin Nephrol. 1991 Dec;36(6):267-73.
10
Interleukin-1 beta stimulates human mesangial cells to synthesize and release interleukins-6 and -8.白细胞介素-1β刺激人系膜细胞合成并释放白细胞介素-6和-8。
Kidney Int. 1991 Oct;40(4):597-605. doi: 10.1038/ki.1991.250.

来自肾小球肾炎患者培养的外周血单核细胞的白细胞介素-8释放

IL-8 release from cultured peripheral blood monocytes of patients with glomerulonephritis.

作者信息

Matsumoto K

机构信息

Second Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan.

出版信息

Clin Exp Immunol. 1995 Jan;99(1):106-11. doi: 10.1111/j.1365-2249.1995.tb03479.x.

DOI:10.1111/j.1365-2249.1995.tb03479.x
PMID:7813101
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1534141/
Abstract

IL-8 is a chemotactic cytokine with proinflammatory and growth-promoting activities. The release of IL-8 was measured in supernatants of cultured peripheral blood monocytes (PBM) that were obtained from patients with glomerulonephritis (GN) and healthy controls. Spontaneous and lipopolysaccharide (LPS)-induced IL-8 release was significantly higher in PBM isolated from patients with IgA nephropathy (IgAN) and membranous nephropathy (MN) compared with normal controls. These results raise the question of whether IL-8 contributes to the ongoing pathogenesis of GN. We cannot relate IL-8 release to clinical and laboratory parameters in IgAN and MN patients. Thus, disease progression in vivo may not be accompanied by increased or sustained IL-8 release.

摘要

白细胞介素-8（IL-8）是一种具有促炎和促生长活性的趋化细胞因子。从肾小球肾炎（GN）患者和健康对照者获取的培养外周血单核细胞（PBM）上清液中检测IL-8的释放情况。与正常对照相比，从IgA肾病（IgAN）和膜性肾病（MN）患者分离出的PBM中，自发和脂多糖（LPS）诱导的IL-8释放显著更高。这些结果提出了一个问题，即IL-8是否参与了GN的持续发病机制。我们无法将IgAN和MN患者的IL-8释放与临床和实验室参数联系起来。因此，体内疾病进展可能不会伴随IL-8释放增加或持续。