采用肉汤微量稀释法测定44株镰刀菌临床分离株的抗真菌药敏性。
Antifungal susceptibility of 44 clinical isolates of Fusarium species determined by using a broth microdilution method.
作者信息
Reuben A, Anaissie E, Nelson P E, Hashem R, Legrand C, Ho D H, Bodey G P
机构信息
Department of Medical Specialities, University of Texas M. D. Anderson Cancer Center, Houston 77030.
出版信息
Antimicrob Agents Chemother. 1989 Sep;33(9):1647-9. doi: 10.1128/AAC.33.9.1647.
Abstract
The MICs and minimum fungicidal concentrations of amphotericin B, natamycin, miconazole, itraconazole, and flucytosine against 17 isolates of Fusarium solani, 14 isolates of Fusarium moniliforme, 10 isolates of Fusarium oxysporum, and 3 isolates of Fusarium semitectum were determined by a broth microdilution method. Amphotericin B and natamycin were the most active agents tested and failed to show any inoculum size effect. In contrast, miconazole and itraconazole showed poor inhibitory and fungicidal activities, and the inoculum size had a major effect on the results. Flucytosine had no activity against any of the isolates tested.
摘要
采用肉汤微量稀释法测定了两性霉素B、游霉素、咪康唑、伊曲康唑和氟胞嘧啶对17株茄病镰刀菌、14株串珠镰刀菌、10株尖孢镰刀菌和3株半裸镰刀菌的最低抑菌浓度（MIC）和最低杀菌浓度。两性霉素B和游霉素是所测试的活性最强的药物，且未表现出任何接种量效应。相比之下，咪康唑和伊曲康唑的抑菌和杀菌活性较差，接种量对结果有重大影响。氟胞嘧啶对所测试的任何分离株均无活性。
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