Tava Valeria, Prigitano Anna, Cortesi Paolo, Esposto Maria Carmela, Pasquali Matias
Dipartimento di Scienze per gli Alimenti, la Nutrizione e l'Ambiente, Università degli Studi di Milano, 20133 Milano, Italy.
Dipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano, 20133 Milano, Italy.
J Fungi (Basel). 2021 Sep 21;7(9):784. doi: 10.3390/jof7090784.
belongs to the species complex. It causes crown rot disease in banana but also keratitis and skin infections as well as systemic infections in immunocompromised patients. Antifungal treatments in clinical and agricultural settings rely mostly on molecules belonging to the azole class. Given the potential risk of pathogen spread from food to clinical settings, the goal of the work was to define the level of susceptibility to different azoles of a worldwide population of . Eight fungicides used in agriculture and five antifungals used in clinical settings (4 azoles and amphotericin B) were tested using the CLSI (Clinical and Laboratory Standards Institute) protocol methodology on 19 strains collected from both infected patients and bananas. The level of susceptibility to the different active molecules was not dependent on the source of isolation with the exception of fenbuconazole and difenoconazole which had a higher efficiency on banana-isolated strains. Minimal inhibitory concentrations (MICs) of the different molecules ranged from 0.12-0.25 mg/L for prochloraz to more than 16 mg/L for tetraconazole and fenbuconazole. Compared to the , MICs were higher suggesting the importance of monitoring the potential future spread of this species also in clinical settings.
属于物种复合体。它会引发香蕉的冠腐病，还会导致角膜炎、皮肤感染以及免疫功能低下患者的全身感染。临床和农业环境中的抗真菌治疗主要依赖于唑类分子。鉴于病原体从食品传播到临床环境的潜在风险，这项工作的目标是确定全球范围内该物种对不同唑类的敏感程度。使用美国临床和实验室标准协会（CLSI）的方案方法，对从感染患者和香蕉中收集的19株菌株测试了8种农业用杀菌剂和5种临床用抗真菌剂（4种唑类和两性霉素B）。除了苯醚甲环唑和苯醚甲环唑对香蕉分离菌株的效率更高外，对不同活性分子的敏感程度并不取决于分离来源。不同分子的最低抑菌浓度（MIC）范围从咪鲜胺的0.12 - 0.25毫克/升，到四氟醚唑和苯醚甲环唑的超过16毫克/升。与[未提及的对比对象]相比，MIC更高，这表明监测该物种在临床环境中未来潜在传播的重要性。
