Catchpole C R, Andrews J M, Brenwald N, Wise R
Department of Microbiology, City Hospital NHS Trust, Birmingham, UK.
J Antimicrob Chemother. 1997 Feb;39(2):255-60. doi: 10.1093/jac/39.2.255.
The in-vitro activity of colistin sulphomethate sodium was compared with that of other commonly used antimicrobial agents against 377 recent clinical isolates of Gram-negative bacteria (including 94 strains of Pseudomonas aeruginosa from patients with cystic fibrosis) and 16 organisms with defined resistance patterns. Colistin was active against most strains of P. aeruginosa (MIC90 4 mg/L), Shigella spp. (MIC90 0.5 mg/L), Salmonella spp. (MIC90 1 mg/L), Acinetobacter spp. (MIC90 2 mg/L), Citrobacter spp. (MIC90 1 mg/L), Escherichia coli (MIC90 1 mg/L), Klebsiella spp. (MIC90 8 mg/L) and Enterobacter spp. (MIC50 1 mg/L). No useful activity was demonstrated against Providentia spp. or Serratia spp. The results show that colistin remains a useful antimicrobial agent against Gram-negative bacteria, particularly those strains which are resistant to more commonly used antibiotics.
将硫酸多黏菌素B钠的体外活性与其他常用抗菌剂针对377株近期临床分离的革兰氏阴性菌（包括94株来自囊性纤维化患者的铜绿假单胞菌）以及16株具有明确耐药模式的微生物的活性进行了比较。多黏菌素对大多数铜绿假单胞菌菌株（MIC90为4mg/L）、志贺菌属（MIC90为0.5mg/L）、沙门菌属（MIC90为1mg/L）、不动杆菌属（MIC90为2mg/L）、枸橼酸杆菌属（MIC90为1mg/L）、大肠埃希菌（MIC90为1mg/L）、克雷伯菌属（MIC90为8mg/L）和肠杆菌属（MIC50为1mg/L）具有活性。对普罗威登斯菌属或沙雷菌属未显示出有效活性。结果表明，多黏菌素仍然是一种针对革兰氏阴性菌的有用抗菌剂，尤其是那些对更常用抗生素耐药的菌株。
