Wang C C, Rogers M S
Department of Obstetrics and Gynaecology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong.
Br J Obstet Gynaecol. 1997 Feb;104(2):251-5. doi: 10.1111/j.1471-0528.1997.tb11055.x.
To examine the relation between cord entanglement around the fetal neck and umbilical arterial measures of free oxygen radical activity at birth.
Prospective observational study of the lipid peroxide levels in umbilical cord arterial blood.
Delivery suite of Prince of Wales Hospital, Hong Kong.
Women with a singleton pregnancy, at term (37 to 42 weeks of gestation), cephalic presentation, spontaneous or induced labour and an initially normal fetal heart rate tracing.
A series of 230 singleton deliveries had determination of two lipoperoxides in umbilical arterial cord blood: malondialdehyde and organic hydroperoxide. Umbilical pH, PO2, PCO2 and base excess were also measured in both umbilical cord arterial and venous blood.
Umbilical cord blood gases and arterial malondialdehyde and organic hydroperoxide levels.
Forty-nine cases of nuchal cord were observed: 14 tight and 35 loose. Tight nuchal cord was associated with a low 1-min Apgar score and increased lipid peroxide levels. Loose nuchal cord was associated with larger amniotic fluid volume and significantly decreased lipid peroxide levels.
This study suggests that tight nuchal cord is associated with increased free oxygen radical activity in the fetus, but that loose nuchal cord carries no adverse effects.
探讨胎儿颈部脐带缠绕与出生时脐动脉游离氧自由基活性指标之间的关系。
对脐动脉血中脂质过氧化物水平进行前瞻性观察研究。
香港威尔士亲王医院产房。
单胎妊娠、足月（妊娠37至42周）、头先露、自然分娩或引产且最初胎儿心率监测正常的孕妇。
对230例单胎分娩的脐动脉血进行两种脂质过氧化物测定：丙二醛和有机氢过氧化物。同时测定脐动脉血和脐静脉血的脐部pH值、PO2、PCO2和碱剩余。
脐血气以及动脉丙二醛和有机氢过氧化物水平。
观察到49例脐带绕颈病例，其中14例为紧绕，35例为松绕。紧绕脐带与1分钟阿氏评分低及脂质过氧化物水平升高有关。松绕脐带与羊水量较多及脂质过氧化物水平显著降低有关。
本研究提示，紧绕脐带与胎儿体内游离氧自由基活性增加有关，但松绕脐带无不良影响。
