Wang C C, Rogers M S
Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories.
Br J Obstet Gynaecol. 1997 Oct;104(10):1140-4. doi: 10.1111/j.1471-0528.1997.tb10937.x.
To assess the effect of amniotic fluid volume on umbilical cord arterial lipid peroxide levels in relation to intrapartum events.
Prospective observational study.
Delivery suite of a teaching hospital, the Chinese University of Hong Kong.
Women with singleton, term, cephalic presentation, and an initially normal fetal heart rate tracing.
All pregnancies had amniotic fluid index assessments before and after amniotomy and cord arterial lipid peroxide determination at delivery. Multiple regression analysis.
Cord arterial malondialdehyde and organic hydroperoxide levels.
In 247 cases following amniotomy levels were inversely correlated with intrapartum amniotic fluid index. Amniotic fluid index during labour was an independent determinant of cord arterial lipid peroxide concentration, along with duration of second stage, absence of epidural, presence of tight nuchal cord entanglement and evidence of fetal distress.
Oligohydramnios during labour is associated with high levels of lipid peroxidation in the fetus, reflecting an increase in hypoxic cellular damage by free radicals.
评估羊水量对脐带动脉脂质过氧化物水平的影响及其与产时事件的关系。
前瞻性观察性研究。
香港中文大学教学医院的分娩室。
单胎、足月、头先露且初始胎心监护正常的孕妇。
所有孕妇在破膜前后进行羊水指数评估，并在分娩时测定脐带动脉脂质过氧化物。采用多元回归分析。
脐带动脉丙二醛和有机氢过氧化物水平。
在247例破膜后的病例中，羊水量与产时羊水指数呈负相关。产程中的羊水指数是脐带动脉脂质过氧化物浓度的独立决定因素，同时还有第二产程时长、未行硬膜外麻醉、存在紧密的脐带绕颈以及胎儿窘迫的证据。
产程中羊水过少与胎儿脂质过氧化水平升高有关，这反映了自由基导致的缺氧细胞损伤增加。
