Ayton Scott, Lei Peng
The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Kenneth Myer Building at Genetics Lane on Royal Parade, Parkville, VIC 3010, Australia.
Biomed Res Int. 2014;2014:581256. doi: 10.1155/2014/581256. Epub 2014 Jan 16.
Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor deficits accompanying degeneration of substantia nigra pars compactor (SNc) neurons. Although familial forms of the disease exist, the cause of sporadic PD is unknown. Symptomatic treatments are available for PD, but there are no disease modifying therapies. While the neurodegenerative processes in PD may be multifactorial, this paper will review the evidence that prooxidant iron elevation in the SNc is an invariable feature of sporadic and familial PD forms, participates in the disease mechanism, and presents as a tractable target for a disease modifying therapy.
帕金森病（PD）是一种神经退行性疾病，其特征是随着黑质致密部（SNc）神经元变性而出现运动功能障碍。尽管存在该疾病的家族性形式，但散发性PD的病因尚不清楚。目前有针对PD的对症治疗方法，但尚无改变疾病进程的疗法。虽然PD中的神经退行性过程可能是多因素的，但本文将综述相关证据，即SNc中促氧化剂铁水平升高是散发性和家族性PD形式的一个不变特征，参与疾病机制，并作为改变疾病进程疗法的一个可处理靶点。
