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宾夕法尼亚州医院和医生死亡率数据的公开发布。一项案例研究。

The public release of hospital and physician mortality data in Pennsylvania. A case study.

作者信息

Localio A R, Hamory B H, Fisher A C, TenHave T R

机构信息

Center for Biostatistics and Epidemiology, Pennsylvania State University College of Medicine, Hershey 17033, USA.

出版信息

Med Care. 1997 Mar;35(3):272-86. doi: 10.1097/00005650-199703000-00007.

DOI:10.1097/00005650-199703000-00007
PMID:9071258
Abstract

OBJECTIVES

Using the public reports of the Pennsylvania Health Care Cost Containment Council on coronary artery bypass graft surgery for 1990 to 1992 as a case study, the authors assess the sensitivity of results to the choice of data and statistical methodology.

METHODS

Using the Council's public-release data, surgical mortality and utilization were reanalyzed by standard linear models, empirical Bayes methods, Monte Carlo simulations, and hierarchical statistical models.

RESULTS

Statistical power calculations demonstrate that the annual volume of bypass surgery for many hospitals and for most surgeons is too small for meaningful mortality comparisons. The number of hospitals and physicians designated as mortality "outliers" in the Council's reports results in part from a failure to adjust critical P values for multiple comparisons. Hierarchical statistical models implemented by mixed effects logistic regression, by contrast, can detect true differences in performance without producing false outliers. Mortality analyses are sensitive to the choice of comorbidities used for severity adjustment of a mortality model. Small-area analyses indicate large differences in the rates of bypass surgery across Pennsylvania, with lower population-based rates of surgery associated with higher population-based inpatient mortality.

CONCLUSIONS

Analyses of mortality by operative procedure, rather than by patient diagnosis, should consider the potential for selection bias caused by the decision to elect surgery. The clinical and statistical issues of operative mortality are sufficiently complex to merit review by independent experts before public release of hospital and physician performance measures.

摘要

目的

以宾夕法尼亚医疗成本控制委员会1990年至1992年冠状动脉搭桥手术的公开报告为案例研究,作者评估结果对数据选择和统计方法的敏感性。

方法

使用该委员会的公开数据,通过标准线性模型、经验贝叶斯方法、蒙特卡罗模拟和分层统计模型对手术死亡率和利用率进行重新分析。

结果

统计功效计算表明,许多医院和大多数外科医生的年度搭桥手术量过小,无法进行有意义的死亡率比较。该委员会报告中被指定为死亡率“异常值”的医院和医生数量,部分是由于未能对多次比较的关键P值进行调整。相比之下,通过混合效应逻辑回归实施的分层统计模型可以检测出真正的性能差异,而不会产生虚假异常值。死亡率分析对用于死亡率模型严重程度调整的共病选择很敏感。小区域分析表明,宾夕法尼亚州各地的搭桥手术率存在很大差异,以人群为基础的较低手术率与以人群为基础的较高住院死亡率相关。

结论

按手术程序而非患者诊断进行死亡率分析时,应考虑选择手术所导致的选择偏倚可能性。手术死亡率的临床和统计问题足够复杂,在公开医院和医生绩效指标之前,应由独立专家进行审查。

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