Tomoda A, Miike T, Miyagawa S, Negi A, Takeshima H
Department of Child Development, Kumamoto University School of Medicine, Japan.
Brain Dev. 1997 Jan;19(1):55-7. doi: 10.1016/s0387-7604(96)00071-x.
This is a case report of a 10-year-old boy with subacute sclerosing panencephalitis (SSPE). He initially developed visual disturbance and macular degenerative changes of the right eye at the age of 8 years, followed by chorioretinitis of the left eye, and his neurological symptoms deteriorated rapidly from the age of 10 years. He was diagnosed as having SSPE, as judged on cerebrospinal fluid examination for measles virus RNA by reverse transcription-polymerase chain reaction (RT-PCR), at the second stage of Jabbour's classification on admission. Although high intensity lesions were observed in the right occipital and temporal lobes, especially around the optic radiation, on T2-weighted brain MRI before the start of intrathecal interferon-alpha (IFN-alpha) therapy, they had disappeared at about two months after the treatment. Chorioretinitis (and/or macular degeneration) should be considered in the differential diagnosis of SSPE, permitting early IFN therapy.
这是一例10岁亚急性硬化性全脑炎（SSPE）男孩的病例报告。他8岁时最初出现右眼视力障碍和黄斑变性改变，随后左眼发生脉络膜视网膜炎，10岁起神经症状迅速恶化。入院时根据脑脊液麻疹病毒RNA逆转录聚合酶链反应（RT-PCR）检测结果，在Jabbour分类的第二阶段被诊断为SSPE。在鞘内注射α干扰素（IFN-α）治疗开始前的T2加权脑MRI上，右侧枕叶和颞叶，尤其是视辐射周围观察到高强度病变，但治疗后约两个月这些病变消失。在SSPE的鉴别诊断中应考虑脉络膜视网膜炎（和/或黄斑变性），以便早期进行IFN治疗。
