Diamond B J, DeLuca J, Kim H, Kelley S M
Kessler Institute for Rehabilitation, Department of Research, West Orange, NJ 07052, USA.
J Clin Exp Neuropsychol. 1997 Feb;19(1):34-42. doi: 10.1080/01688639708403834.
The present study was conducted to investigate the hypothesis that subjects with MS have a disproportionate impairment in the phonological loop of working memory and whether such impairment is domain-specific. This was assessed by comparing performance in subjects with MS across both the visual (using the Paced Visual Serial Addition Test: PVSAT) and auditory (using the Paced Auditory Serial Addition Test: PASAT) domains. In addition, we assessed the role of processing speed in mediating performance deficits. The results showed that: (1) Although all subjects performed better on the PVSAT versus the PASAT, no disproportionate modality-specific differences were observed in the MS group relative to controls; and (2) the rate of decline across trials in the MS and healthy control groups did not differ on either the PVSAT or PASAT. Implications of the results are discussed within the context of a working memory model.
本研究旨在探讨多发性硬化症（MS）患者在工作记忆的语音回路中存在不成比例的损伤这一假设，以及这种损伤是否具有领域特异性。通过比较MS患者在视觉领域（使用视觉序列加法测试：PVSAT）和听觉领域（使用听觉序列加法测试：PASAT）的表现来进行评估。此外，我们评估了处理速度在介导表现缺陷中的作用。结果表明：（1）尽管所有受试者在PVSAT上的表现均优于PASAT，但与对照组相比，MS组未观察到不成比例的模态特异性差异；（2）MS组和健康对照组在PVSAT或PASAT上各试验的下降速率没有差异。在工作记忆模型的背景下讨论了结果的意义。
