Rudas M, Neumayer R, Gnant M F, Mittelböck M, Jakesz R, Reiner A
Institute for Clinical Pathology, University of Vienna, Austria.
Eur J Cancer. 1997 Jan;33(1):39-44. doi: 10.1016/s0959-8049(96)00368-1.
p53 and c-erbB-2 expression, and their correlation with cell proliferation and steroid hormone receptors, were investigated in 121 carcinomas, 23 lobular in situ carcinomas (LCIS), 74 intraductal carcinomas (DCIS) and 24 minimal invasive carcinomas. DCIS were classified according to the EORTC classification. All markers were measured immunohistochemically on paraffin sections. None of the LCIS, 9 DCIS and 9 minimal invasive cancers showed nuclear positivity for p53. A strong association between histological type and p53 expression was found. Proliferation rates correlated with p53 expression. c-erbB-2 positivity was found in 1 LCIS, 27 DCIS and 12 minimal invasive cancers. There was a significant correlation between p53 expression and c-erbB-2. Both parameters were associated with high proliferation rate and negativity for steroid hormone receptor status. Nuclear pleomorphism could become a comparable prognostic marker in DCIS as it is for infiltrating carcinomas.
在121例癌、23例小叶原位癌（LCIS）、74例导管内癌（DCIS）和24例微浸润癌中，研究了p53和c-erbB-2的表达及其与细胞增殖和类固醇激素受体的相关性。DCIS根据欧洲癌症研究与治疗组织（EORTC）分类进行分类。所有标志物均在石蜡切片上采用免疫组织化学方法测定。LCIS、9例DCIS和9例微浸润癌均未显示p53核阳性。发现组织学类型与p53表达之间存在强关联。增殖率与p53表达相关。在1例LCIS、27例DCIS和12例微浸润癌中发现c-erbB-2阳性。p53表达与c-erbB-2之间存在显著相关性。这两个参数均与高增殖率和类固醇激素受体状态阴性相关。核多形性在DCIS中可能成为与浸润性癌类似的预后标志物。
