Posokhova K A
Lik Sprava. 1996 Jul-Sep(7-9):65-8.
Inductors of the microsomal enzymes phenobarbital and, to a lesser extent, cordiamine stimulate the biligenic function of the liver, while the inhibitor monooxigenases cymetidine depresses it. Employment of bile-expelling agents, such as cholic and dehydrocholic acids, sodium selenate, under conditions of induction of microsomal enzymes is associated with a more pronounced bile-expelling effect than their being administered separately. Stimulating effect of oxafenamide on bile production occurs against the background of phenobarbital induction of microsomal enzymes and is not found if the drug is used together with cordiamine. Administration of oxafenamide in the presence of inhibition of bile production induced by cimetidine does not result in normalization of this function of the liver.
微粒体酶诱导剂苯巴比妥以及在较小程度上的可拉明刺激肝脏的胆生成功能，而单加氧酶抑制剂西咪替丁则抑制该功能。在微粒体酶诱导的情况下使用利胆剂，如胆酸、去氢胆酸、硒酸钠，与单独给药相比，利胆效果更显著。奥沙酰胺对胆汁生成的刺激作用是在苯巴比妥诱导微粒体酶的背景下出现的，如果该药物与可拉明一起使用则不会出现这种作用。在西咪替丁诱导胆汁生成受抑制存在的情况下给予奥沙酰胺，不会使肝脏的这一功能恢复正常。
