[A pharmacological analysis of liver secretory function under altered microsomal enzyme activity].

Inductors of the microsomal enzymes phenobarbital and, to a lesser extent, cordiamine stimulate the biligenic function of the liver, while the inhibitor monooxigenases cymetidine depresses it. Employment of bile-expelling agents, such as cholic and dehydrocholic acids, sodium selenate, under conditions of induction of microsomal enzymes is associated with a more pronounced bile-expelling effect than their being administered separately. Stimulating effect of oxafenamide on bile production occurs against the background of phenobarbital induction of microsomal enzymes and is not found if the drug is used together with cordiamine. Administration of oxafenamide in the presence of inhibition of bile production induced by cimetidine does not result in normalization of this function of the liver.