肽核酸在癌症治疗中的应用。

Application of peptide nucleic acid in cancer therapy.

作者信息

Knudsen H, Nielsen P E

机构信息

Department of Medical Biochemistry & Genetics, The Panum Institute, Copenhagen N, Denmark.

出版信息

Anticancer Drugs. 1997 Feb;8(2):113-8. doi: 10.1097/00001813-199702000-00002.

DOI:10.1097/00001813-199702000-00002

PMID:9073307

Abstract

Peptide nucleic acid (PNA) is a DNA mimic with a pseudopeptide backbone composed of aminoethyl glycine units. Several features of PNA, such as superior hybridization affinities to RNA and DNA, high biological stability, and convenient solid-phase synthesis, make it a promising candidate for use as a gene targeting drug. Here we review the chemical and biological properties of PNA in relation to its potential as an anti-cancer drug.

摘要

肽核酸（PNA）是一种具有由氨基乙基甘氨酸单元组成的假肽主链的DNA模拟物。PNA的几个特性，如对RNA和DNA具有卓越的杂交亲和力、高生物稳定性以及便捷的固相合成，使其成为一种有前景的基因靶向药物候选物。在此，我们综述PNA的化学和生物学特性及其作为抗癌药物的潜力。