肽核酸（PNA）。一种具有肽主链的DNA模拟物。 - Suppr

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Peptide nucleic acid (PNA). A DNA mimic with a peptide backbone.

作者信息

Nielsen P E, Egholm M, Buchardt O

机构信息

Department of Biochemistry B, Panum Institute, Copenhagen, Denmark.

出版信息

Bioconjug Chem. 1994 Jan-Feb;5(1):3-7. doi: 10.1021/bc00025a001.

DOI:10.1021/bc00025a001

PMID:8199231

Abstract

摘要

相似文献

Peptide nucleic acid (PNA). A DNA mimic with a peptide backbone.

Bioconjug Chem. 1994 Jan-Feb;5(1):3-7. doi: 10.1021/bc00025a001.

Peptide nucleic acids (PNA): synthesis, properties and potential applications.

Bioorg Med Chem. 1996 Jan;4(1):5-23. doi: 10.1016/0968-0896(95)00171-9.

Application of peptide nucleic acid in cancer therapy.

Anticancer Drugs. 1997 Feb;8(2):113-8. doi: 10.1097/00001813-199702000-00002.

Peptide nucleic acids and their potential applications in biotechnology.

Trends Biotechnol. 1993 Sep;11(9):384-6. doi: 10.1016/0167-7799(93)90097-S.

Peptide nucleic acid (PNA): a model structure for the primordial genetic material?

Orig Life Evol Biosph. 1993 Dec;23(5-6):323-7. doi: 10.1007/BF01582083.

Solid-phase synthesis of peptide nucleic acids.

J Pept Sci. 1995 May-Jun;1(3):175-83. doi: 10.1002/psc.310010304.

Peptide nucleic acid (PNA)/DNA hybrid duplexes: intercalation by an internally linked anthraquinone.

Nucleic Acids Res. 1998 Feb 1;26(3):715-20. doi: 10.1093/nar/26.3.715.

Monofunctionally trans-diammine platinum(II)-modified peptide nucleic acid oligomers: a new generation of potential antisense drugs.

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Progress in developing PNA as a gene-targeted drug.

Antisense Nucleic Acid Drug Dev. 1997 Aug;7(4):431-7. doi: 10.1089/oli.1.1997.7.431.

Targeting double stranded DNA with peptide nucleic acid (PNA).

Curr Med Chem. 2001 Apr;8(5):545-50. doi: 10.2174/0929867003373373.

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Thyclotides, tetrahydrofuran-modified peptide nucleic acids that efficiently penetrate cells and inhibit microRNA-21.

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Antispacer peptide nucleic acids for sequence-specific CRISPR-Cas9 modulation.

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Peptide nucleic acid (PNA). A DNA mimic with a peptide backbone.

作者信息

Nielsen P E, Egholm M, Buchardt O

机构信息

Department of Biochemistry B, Panum Institute, Copenhagen, Denmark.

出版信息

Bioconjug Chem. 1994 Jan-Feb;5(1):3-7. doi: 10.1021/bc00025a001.

DOI:10.1021/bc00025a001

PMID:8199231

Abstract

摘要

相似文献

Peptide nucleic acid (PNA). A DNA mimic with a peptide backbone.

Bioconjug Chem. 1994 Jan-Feb;5(1):3-7. doi: 10.1021/bc00025a001.

Peptide nucleic acids (PNA): synthesis, properties and potential applications.

Bioorg Med Chem. 1996 Jan;4(1):5-23. doi: 10.1016/0968-0896(95)00171-9.

Application of peptide nucleic acid in cancer therapy.

Anticancer Drugs. 1997 Feb;8(2):113-8. doi: 10.1097/00001813-199702000-00002.

Peptide nucleic acids and their potential applications in biotechnology.

Trends Biotechnol. 1993 Sep;11(9):384-6. doi: 10.1016/0167-7799(93)90097-S.

Peptide nucleic acid (PNA): a model structure for the primordial genetic material?

Orig Life Evol Biosph. 1993 Dec;23(5-6):323-7. doi: 10.1007/BF01582083.

Solid-phase synthesis of peptide nucleic acids.

J Pept Sci. 1995 May-Jun;1(3):175-83. doi: 10.1002/psc.310010304.

Peptide nucleic acid (PNA)/DNA hybrid duplexes: intercalation by an internally linked anthraquinone.

Nucleic Acids Res. 1998 Feb 1;26(3):715-20. doi: 10.1093/nar/26.3.715.

Monofunctionally trans-diammine platinum(II)-modified peptide nucleic acid oligomers: a new generation of potential antisense drugs.

Chemistry. 2002 Dec 16;8(24):5566-70. doi: 10.1002/1521-3765(20021216)8:24<5566::AID-CHEM5566>3.0.CO;2-#.

Progress in developing PNA as a gene-targeted drug.

Antisense Nucleic Acid Drug Dev. 1997 Aug;7(4):431-7. doi: 10.1089/oli.1.1997.7.431.

Targeting double stranded DNA with peptide nucleic acid (PNA).

Curr Med Chem. 2001 Apr;8(5):545-50. doi: 10.2174/0929867003373373.

引用本文的文献

Construction of Graphene Oxide Probes Loaded with Antisense Peptide Nucleic Acid and Doxorubicin for Regulating Telomerase Activity and Inducing Apoptosis of Cancer Cells.

Biosensors (Basel). 2025 May 26;15(6):337. doi: 10.3390/bios15060337.

Luminescent Iridium-Peptide Nucleic Acid Bioconjugate as Photosensitizer for Singlet Oxygen Production toward a Potential Dual Therapeutic Agent.

Inorg Chem. 2025 Apr 14;64(14):6898-6911. doi: 10.1021/acs.inorgchem.4c05359. Epub 2025 Mar 27.

Multicomponent Synthesis of C(8)-Substituted Purine Building Blocks of Peptide Nucleic Acids from Prebiotic Compounds.

ChemistryOpen. 2024 Dec;13(12):e202400265. doi: 10.1002/open.202400265. Epub 2024 Oct 17.

Peptide Nucleic Acid-Mediated Regulation of CRISPR-Cas9 Specificity.

Nucleic Acid Ther. 2024 Oct;34(5):245-256. doi: 10.1089/nat.2024.0007. Epub 2024 Jul 22.

miR-142: A Master Regulator in Hematological Malignancies and Therapeutic Opportunities.

Cells. 2023 Dec 30;13(1):84. doi: 10.3390/cells13010084.

MicroRNA 29a therapy for CEACAM6-expressing lung adenocarcinoma.

BMC Cancer. 2023 Sep 8;23(1):843. doi: 10.1186/s12885-023-11352-w.

Forced Intercalation Peptide Nucleic Acid Probes for the Detection of an Adenosine-to-Inosine Modification.

ACS Omega. 2022 Dec 22;8(1):238-248. doi: 10.1021/acsomega.2c03568. eCollection 2023 Jan 10.

Thyclotides, tetrahydrofuran-modified peptide nucleic acids that efficiently penetrate cells and inhibit microRNA-21.

Nucleic Acids Res. 2022 Oct 28;50(19):10839-10856. doi: 10.1093/nar/gkac864.

Antispacer peptide nucleic acids for sequence-specific CRISPR-Cas9 modulation.

Nucleic Acids Res. 2022 Jun 10;50(10):e59. doi: 10.1093/nar/gkac095.

Different Schiff Bases-Structure, Importance and Classification.

Molecules. 2022 Jan 25;27(3):787. doi: 10.3390/molecules27030787.