Sharma P, Page M J, Poritz L S, Koltun W A, Chorney M J
Department of Microbiology, Pennsylvania State University College of Medicine, Hershey 17033, USA.
Cell Immunol. 1997 Mar 15;176(2):153-7. doi: 10.1006/cimm.1996.1076.
In an approach to study thymic leukemia antigen's (TL's) function, we have developed transgenic mice that express T18d on virtually all somatic cells; in such mice, we initially observed changes in T cells within the thymus and lymph nodes as well as the ability of TL to undergo recognition by splenic T cells. As phase II of our study, we now present the results on the composition of gut T cell populations which may be a better measure of TL's true function. We have demonstrated an increase in the number of gamma delta T cells as well as the increase in gamma delta T cells expressing the V gamma 2 chain. These cells appear to be both CD4 and CD8 negative. This suggests that TL may select for a subset of gamma delta T cells within the gut and bolsters earlier reports implicating an H-2T regional gene product as the major histocompatibility complex ligand for gamma delta T cells.
在一项研究胸腺白血病抗原（TL）功能的实验中，我们培育出了在几乎所有体细胞中都表达T18d的转基因小鼠；在这些小鼠中，我们最初观察到胸腺和淋巴结内T细胞的变化，以及脾脏T细胞对TL的识别能力。作为我们研究的第二阶段，我们现在展示关于肠道T细胞群体组成的结果，这可能是衡量TL真正功能的更好指标。我们已经证明γδT细胞数量增加，以及表达Vγ2链的γδT细胞数量增加。这些细胞似乎同时为CD4和CD8阴性。这表明TL可能在肠道内选择了γδT细胞的一个亚群，并支持了早期的报告，即H-2T区域基因产物作为γδT细胞的主要组织相容性复合体配体。
