Perrot H, Germain D, Euvrard S, Thivolet J
Arch Dermatol Res (1975). 1977 Aug 22;259(2):177-85. doi: 10.1007/BF00557959.
The authors studied by electron microscope, the sun-exposed skin of the back of the hand from three heavily hemodialysed patients with a porphyria cutanea tarda-like bullous skin disease. The vascular impairment, like that of PCT, closely resembles that seen during medicamentous phototoxic processes. The connective tissue is infiltrated by large granulo-filamentous masses and the fibroblasts are secretory in appearance. At the dermal-epidermal junction, the abnormalities are important, with a diffuse infiltration of the upper dermis by a hyalin substance, probably resulting in a collagen degeneration and cellular necrosis. The aetiological factors are uncertain, as no common medicamentous factor appeared in our patients, and as the plasticizers used in the hemodialysis tubes probably played no part.
作者通过电子显微镜研究了3例患有迟发性皮肤卟啉病样大疱性皮肤病的重度血液透析患者手背部暴露于阳光下的皮肤。其血管损伤与迟发性皮肤卟啉病的血管损伤相似，与药物性光毒性过程中所见的损伤极为相似。结缔组织被大量颗粒状细丝状物质浸润，成纤维细胞呈分泌状外观。在真皮-表皮交界处，异常情况较为严重，透明质物质弥漫性浸润真皮上层，可能导致胶原变性和细胞坏死。病因尚不确定，因为我们的患者中未出现常见的药物因素，且血液透析管中使用的增塑剂可能也不起作用。
