Takita H, Merrin C, Didolkar M S, Douglass H O, Edgerton F
Ann Thorac Surg. 1977 Oct;24(4):359-64. doi: 10.1016/s0003-4975(10)63415-7.
From 1970 to June, 1976, 56 patients who had multiple metastatic tumors of the lung were treated by lung resection. Most of the bilateral lung lesions were removed through a median sternotomy so as to avoid staged bilateral thoracotomy. The surgical mortality was 1.8%. A total of 26 patients are alive at 7 to 69 months (estimated median survival, 20.7 months). Patients with tumor doubling time of less than 40 days had lower survival results (median, 9.5 months), compared to patients with tumor doubling time of more than 40 days (median not yet reached). The type of primary tumor, tumor-free interval, number of lesions removed, and presence of unilateral as opposed to bilateral lung metastases did not seem to affect the therapeutic results.
1970年至1976年6月，56例患有多发性肺转移瘤的患者接受了肺切除术。大多数双侧肺部病变通过正中胸骨切开术切除，以避免分期双侧开胸手术。手术死亡率为1.8%。共有26例患者存活7至69个月（估计中位生存期为20.7个月）。肿瘤倍增时间小于40天的患者生存结果较低（中位生存期为9.5个月），而肿瘤倍增时间大于40天的患者（中位生存期尚未达到）。原发肿瘤类型、无瘤间期、切除的病变数量以及单侧与双侧肺转移的存在似乎不影响治疗结果。
