使用[1-¹¹C]乙酸测量心肌耗氧量的房室模型。

Compartment model for measuring myocardial oxygen consumption using [1-11C]acetate.

作者信息

Sun K T, Chen K, Huang S C, Buxton D B, Hansen H W, Kim A S, Siegel S, Choi Y, Müller P, Phelps M E, Schelbert H R

机构信息

Department of Molecular and Medical Pharmacology, UCLA School of Medicine 90095, USA.

出版信息

J Nucl Med. 1997 Mar;38(3):459-66.

PMID:9074539

Abstract

UNLABELLED

Although [1-11C]acetate has been validated as a PET tracer for myocardial oxygen consumption (MVO2) in animals and humans, mono- and biexponential fitting of the tissue time-activity curve yields only estimates of MVO2. This study attempts to develop and validate a simple tracer kinetic model in vivo for estimation of regional MVO2.

METHODS

Twenty-seven experiments were performed in 12 anesthetized dogs with [1-11C]acetate and serial PET images under different MBF and MVO2 (baseline, ischemia, xylazine, dobutamine and dipyridamole). Estimates of MVO2 were obtained from dynamic [1-11C]acetate PET and model fitting. MBF was measured by radiolabeled microspheres, and MVO2 was calculated by the Fick method using arterial and coronary blood samples.

RESULTS

The proposed model fitted equally well for all study conditions with a multiple correlation coefficient of 0.985 +/- 0.026. Estimated MVO2 correlated linearly with measured MVO2 (y = 0.033 + 0.690x, r = 0.92, s.e. of estimates = 0.020).

CONCLUSION

This study indicates that MVO2 can be assessed with PET and [1-11C]acetate over a wide range with a simple tracer kinetic model.

摘要

未标注

尽管[1-11C]乙酸已被验证为动物和人类心肌氧耗（MVO2）的正电子发射断层显像（PET）示踪剂，但组织时间-活度曲线的单指数和双指数拟合仅能得出MVO2的估计值。本研究试图开发并验证一种用于体内估计局部MVO2的简单示踪剂动力学模型。

方法

对12只麻醉犬进行了27次实验，使用[1-11C]乙酸并在不同心肌血流量（MBF）和MVO2（基线、缺血、赛拉嗪、多巴酚丁胺和双嘧达莫）条件下采集连续PET图像。从动态[1-11C]乙酸PET和模型拟合中获得MVO2的估计值。通过放射性微球测量MBF，并使用动脉和冠状动脉血样通过菲克法计算MVO2。