血流介导的内皮细胞机械转导早期信号事件中的空间关系。

Spatial relationships in early signaling events of flow-mediated endothelial mechanotransduction.

作者信息

Davies P F, Barbee K A, Volin M V, Robotewskyj A, Chen J, Joseph L, Griem M L, Wernick M N, Jacobs E, Polacek D C, dePaola N, Barakat A I

机构信息

Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia 19104, USA.

出版信息

Annu Rev Physiol. 1997;59:527-49. doi: 10.1146/annurev.physiol.59.1.527.

DOI:10.1146/annurev.physiol.59.1.527

PMID:9074776

Abstract

Blood flow interactions with the vascular endothelium represent a specialized example of mechanical regulation of cell function that has important physiological and pathological cardiovascular consequences. The endothelial monolayer in vivo acts as a signal transduction interface for forces associated with flowing blood (hemodynamic forces) in the acute regulation of artery tone and chronic structural remodeling of arteries, including the pathology of atherosclerosis. Mechanisms related to spatial relationships at the cell surfaces and throughout the cell that influence flow-mediated endothelial mechanotransduction are discussed. In particular, flow-mediated ion channel activation and cytoskeletal dynamics are considered in relation to topographic analyses of the luminal and abluminal surfaces of living endothelial cells.

摘要

血流与血管内皮之间的相互作用代表了细胞功能机械调节的一个特殊例子，这对心血管生理和病理过程具有重要影响。体内的内皮单层在动脉张力的急性调节和动脉慢性结构重塑（包括动脉粥样硬化病理过程）中，作为与流动血液相关的力（血流动力学力）的信号转导界面。本文讨论了与细胞表面及整个细胞内影响血流介导的内皮机械转导的空间关系相关的机制。特别是，结合对活内皮细胞管腔面和腔外表面的拓扑分析，探讨了血流介导的离子通道激活和细胞骨架动力学。