Davies P F
Department of Pathology, Pritzker School of Medicine, University of Chicago, Illinois, USA.
Physiol Rev. 1995 Jul;75(3):519-60. doi: 10.1152/physrev.1995.75.3.519.
Mechanical forces associated with blood flow play important roles in the acute control of vascular tone, the regulation of arterial structure and remodeling, and the localization of atherosclerotic lesions. Major regulation of the blood vessel responses occurs by the action of hemodynamic shear stresses on the endothelium. The transmission of hemodynamic forces throughout the endothelium and the mechanotransduction mechanisms that lead to biophysical, biochemical, and gene regulatory responses of endothelial cells to hemodynamic shear stresses are reviewed.
与血流相关的机械力在血管张力的急性控制、动脉结构的调节与重塑以及动脉粥样硬化病变的定位中发挥着重要作用。血管反应的主要调节是通过血流动力学剪切应力作用于内皮细胞来实现的。本文综述了血流动力学力在内皮细胞中的传递以及导致内皮细胞对血流动力学剪切应力产生生物物理、生化和基因调节反应的机械转导机制。
