Orrenius S, McConkey D J, Bellomo G, Nicotera P
Trends Pharmacol Sci. 1989 Jul;10(7):281-5. doi: 10.1016/0165-6147(89)90029-1.
Recent work has shown that a sustained increase in cytosolic Ca2+ concentration is often linked to the onset of cytotoxicity. Sten Orrenius and colleagues describe several biochemical mechanisms that are stimulated by such a Ca2+ increase and can directly mediate cell death by causing disruption of the cytoskeleton, DNA fragmentation and extensive damage to other cell components.
最近的研究表明，胞质Ca2+浓度的持续升高通常与细胞毒性的发生有关。斯滕·奥雷纽斯及其同事描述了几种受这种Ca2+升高刺激的生化机制，这些机制可通过导致细胞骨架破坏、DNA片段化以及对其他细胞成分的广泛损伤直接介导细胞死亡。
