Canzian F
Unit of Genetic Cancer Susceptibility, International Agency for Research on Cancer, Lyon, France.
Genome Res. 1997 Mar;7(3):262-7. doi: 10.1101/gr.7.3.262.
A genealogic tree was constructed for inbred strains of the laboratory rat, including 63 strains and 214 of their substrains. Information on genetic and biochemical marker typings of these lines was collected from the literature and from the World Wide Web. Data on 995 polymorphisms were processed into a phylogenetic distance matrix, and a tree was obtained by the Fitch-Margoliash distance matrix method. The inbred strains of the laboratory rat showed an average polymorphism for pairwise comparison of 53%. Strain BN showed the highest genetic divergence from all the other ones. Comparison with the mouse phylogenetic tree indicated that laboratory rats possess a higher diversity than inbred strains of mice not derived from wild species. These results provide a phylogenetic basis in the choice of rat strains for genetic linkage experiments.
构建了实验室大鼠近交系的系谱树，包括63个品系及其214个亚系。这些品系的遗传和生化标记分型信息是从文献和万维网上收集的。将995个多态性数据处理成系统发育距离矩阵，并通过Fitch-Margoliash距离矩阵法获得一棵树。实验室大鼠近交系在两两比较中显示出平均53%的多态性。BN品系与所有其他品系的遗传差异最大。与小鼠系统发育树的比较表明，实验室大鼠比非野生来源的小鼠近交系具有更高的多样性。这些结果为遗传连锁实验中大鼠品系的选择提供了系统发育基础。
