Kiang D T, Kennedy B J
Cancer. 1977 Oct;40(4):1571-6. doi: 10.1002/1097-0142(197710)40:4<1571::aid-cncr2820400429>3.0.co;2-5.
Estrogen receptor contents (ER), determined by a sucrose gradient method in 250 primary or metastatic breast cancers, were analyzed with respect to the influence of the patient's menopausal status, chemotherapy, and tissue sampling. The incidence of the presence of estrogen receptors (ER+) increased in the order of para-, pre- and postmenopausal status of the patient, suggesting that a tumor occurring at the paramenopausal phase tends to be a hormone-independent type. Chemotherapy did not alter the incidence of ER(+), nor the quantity of ER in metastatic lesions. Multiple biopsies done simultaneously or sequentially in the same patient are consistent in their qualities and quantities of ER, provided histological confirmation and examination of the amount of cellularity are included in the process of interpretation.
采用蔗糖梯度法对250例原发性或转移性乳腺癌中的雌激素受体含量（ER）进行测定，并就患者绝经状态、化疗及组织取样的影响进行分析。雌激素受体阳性（ER+）的发生率依患者绝经前、绝经中及绝经后的顺序递增，这表明绝经中期发生的肿瘤往往是激素非依赖型。化疗并未改变ER（+）的发生率，也未改变转移灶中ER的含量。在同一患者中同时或序贯进行的多次活检，其ER的质量和数量是一致的，前提是在解读过程中纳入组织学确认及细胞量检查。
