Cain D P, Saucier D, Boon F
Department of Psychology and Graduate Program in Neuroscience, University of Western Ontario, London, Canada.
Behav Brain Res. 1997 Mar;84(1-2):179-93. doi: 10.1016/s0166-4328(96)00149-0.
The role of NMDA receptors and NMDA-mediated hippocampal long-term potentiation (LTP) in spatial learning was studied in rats using the competitive, systemically administered NMDA receptor antagonists CGS19755 ((+/-)-cis-4-phosphonomethyl-2-piperidine carboxylic acid) and NPC17742 (2R,4R,5S-2-amino-4,5-(1,2-cyclohexyl)-7-phosphonoheptanoic acid). CGS19755 caused sensorimotor disturbances and disrupted acquisition of the water maze in naive rats. The sensorimotor disturbances were greatly reduced and maze learning was normal in spite of the blockade of dentate gyrus LTP by CGS19755 in rats that had first been familiarized with the general task requirements by non-spatial pretraining. In a second experiment, antagonism of NMDA receptors caused small, but reliable, impairments in Y-maze and visible platform visual discrimination tasks. The results indicate that NMDA receptors are not crucial for water maze acquisition using a spatial learning strategy, and that NMDA antagonists cause visual and other sensorimotor disturbances in naive rats that could help account for their poor performance in this task.
利用竞争性、全身给药的NMDA受体拮抗剂CGS19755（（±）-顺式-4-膦酰甲基-2-哌啶羧酸）和NPC17742（2R,4R,5S-2-氨基-4,5-（1,2-环己基）-7-膦酰庚酸），在大鼠中研究了NMDA受体和NMDA介导的海马长时程增强（LTP）在空间学习中的作用。CGS19755导致幼稚大鼠出现感觉运动障碍，并干扰水迷宫实验的习得。在通过非空间预训练首先熟悉一般任务要求的大鼠中，尽管CGS19755阻断了齿状回LTP，但感觉运动障碍大大减轻，迷宫学习正常。在第二个实验中，NMDA受体拮抗剂在Y迷宫和可见平台视觉辨别任务中造成了小而可靠的损伤。结果表明，NMDA受体对于使用空间学习策略进行水迷宫实验的习得并非至关重要，并且NMDA拮抗剂会在幼稚大鼠中引起视觉和其他感觉运动障碍，这可能有助于解释它们在该任务中的不佳表现。
