Warburton E C, Harrison A A, Robbins T W, Everitt B J
Department of Experimental Psychology, University of Cambridge, UK.
Behav Brain Res. 1997 Mar;84(1-2):247-58. doi: 10.1016/s0166-4328(96)00154-4.
The present study compared the effects of systemic 8-OH-DPAT (0.05, 0.1 and 1.0 mg/kg) with intra-raphe and intra-hippocampal infusions of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) (10, 30 100 ng) on delayed non-matching-to-position (DNMP) performance in rats. The highest dose of 8-OH-DPAT administered systemically impaired DNMP performance in a delay-independent manner, increased premature responding and increased response bias. Infusions of 8-OH-DPAT (100 ng) into the median raphe nucleus improved performance accuracy, independent of delay whilst having no effect on any other response measure. Infusions of 8-OH-DPAT into the dorsal raphe nucleus had no effect on performance at any dose tested. Infusions of 8-OH-DPAT into the dorsal hippocampus produced a small impairment in performance which was also independent of delay. However, this decrement in performance accuracy was not accompanied by any changes in other response measures. These findings demonstrate a dissociation between the effects of stimulation of pre- and post-synaptic 5-HT1A receptors on performance of a DNMP task although the changes in performance cannot be accounted for by changes in mnemonic function.
本研究比较了全身注射8-羟基-2-（二正丙基氨基）四氢萘（8-OH-DPAT）（0.05、0.1和1.0毫克/千克）与在中缝核和海马体内注射8-OH-DPAT（10、30、100纳克）对大鼠延迟位置匹配（DNMP）行为表现的影响。全身注射最高剂量的8-OH-DPAT以与延迟无关的方式损害了DNMP行为表现，增加了过早反应并增加了反应偏差。向中缝正中核注射8-OH-DPAT（100纳克）可提高行为表现的准确性，与延迟无关，同时对任何其他反应指标均无影响。向中缝背核注射任何测试剂量的8-OH-DPAT对行为表现均无影响。向背侧海马体注射8-OH-DPAT会导致行为表现出现轻微损害，这也与延迟无关。然而，行为表现准确性的这种下降并未伴随着其他反应指标的任何变化。这些发现表明，尽管行为表现的变化不能用记忆功能的变化来解释，但刺激突触前和突触后5-HT1A受体对DNMP任务行为表现的影响之间存在分离。
