Martikainen Ilkka K, Hirvonen Jussi, Pesonen Ullamari, Hagelberg Nora, Laurikainen Heikki, Tuikkala Heikki, Kajander Jaana, Någren Kjell, Hietala Jarmo, Pertovaara Antti
Department of Physiology, Institute of Biomedicine, University of Turku, Kiinamyllynkatu 10, Turku 20520, Finland
J Neural Transm (Vienna). 2009 Jul;116(7):821-30. doi: 10.1007/s00702-009-0248-3. Epub 2009 Jun 17.
We studied whether brain serotonin 5-HT(1A) receptor availability is associated with response to noxious heat versus tactile stimuli, and short-term memory for heat pain. Psychophysical performance was assessed in 16 healthy subjects who had participated in a positron emission tomography study using [carbonyl-11C]WAY-100635 ligand for the assessment of 5-HT(1A) receptor binding potential (BP (ND)). Signal detection theory was applied to allow separate analysis of the subject's sensory-discriminative capacity (sensory factor) and the attitude toward reporting a sensation (response criterion; non-sensory factor). Subject's response criterion for heat pain was inversely correlated with 5-HT(1A) BP (ND) in the dorsal raphe, middle temporal gyrus, orbitofrontal cortex and posterior cingulum, whereas the subject's discriminative capacity for touch was inversely correlated with 5-HT(1A) BP (ND) in the cingulum, inferior temporal gyrus, and medial prefrontal cortex. Certainty ratings of the responses, but not hit rates, in the pain memory task were correlated with 5-HT(1A) BP (ND) in the dorsal raphe.
我们研究了大脑中血清素5-HT(1A)受体的可用性是否与对热痛刺激和触觉刺激的反应以及热痛的短期记忆相关。对16名健康受试者的心理物理表现进行了评估，这些受试者参与了一项正电子发射断层扫描研究，使用[羰基-11C]WAY-100635配体来评估5-HT(1A)受体结合潜能（BP(ND)）。应用信号检测理论来分别分析受试者的感觉辨别能力（感觉因素）和报告感觉的态度（反应标准；非感觉因素）。受试者对热痛的反应标准与中缝背核、颞中回、眶额皮质和后扣带回中的5-HT(1A) BP(ND)呈负相关，而受试者对触觉的辨别能力与扣带回、颞下回和内侧前额叶皮质中的5-HT(1A) BP(ND)呈负相关。疼痛记忆任务中的反应确定性评分（而非命中率）与中缝背核中的5-HT(1A) BP(ND)相关。
