Herremans A H, Hijzen T H, Olivier B
Solvay Duphar, CNS Pharmacology, DA Weesp, Netherlands.
Behav Brain Res. 1997 Mar;84(1-2):291-9. doi: 10.1016/s0166-4328(97)83336-0.
Effects of bilateral infusions of cholinergic drugs into the dorsal part of the medial prefrontal cortex (dmPFC) on performance in a delayed conditional discrimination (DCD) task were examined in rats. Scopolamine dose-dependently impaired performance. No delay-dependent effect was found indicating that scopolamine did not specifically affect working memory (WM). Physostigmine alone induced a slight improvement of DCD performance independent of delay and co-administration of physostigmine with scopolamine attenuated the scopolamine-induced impairment of DCD performance. Infusion of the muscarinic M2 antagonist AQRA-471, the M3 antagonist 4-DAMP and the mixed M1-M3 antagonist UH-AH 37 did not affect performance in the DCD task, suggesting that the effect of scopolamine is not mediated by a single muscarinic receptor subtype. The results furthermore indicate that the cholinergic system in the dmPFC does not play a specific role in WM processes in the DCD task. Furthermore, the results suggest that the dmPFC cholinergic system plays a role in the attentional processes involved in the DCD task.
研究了向大鼠内侧前额叶皮质背侧（dmPFC）双侧输注胆碱能药物对延迟条件辨别（DCD）任务表现的影响。东莨菪碱剂量依赖性地损害了任务表现。未发现延迟依赖性效应，表明东莨菪碱并未特异性影响工作记忆（WM）。单独使用毒扁豆碱可使DCD任务表现略有改善，且与延迟无关，毒扁豆碱与东莨菪碱联合给药可减轻东莨菪碱诱导的DCD任务表现损害。输注毒蕈碱M2拮抗剂AQRA - 471、M3拮抗剂4 - DAMP和M1 - M3混合拮抗剂UH - AH 37均不影响DCD任务的表现，提示东莨菪碱的作用并非由单一毒蕈碱受体亚型介导。结果还表明，dmPFC中的胆碱能系统在DCD任务的WM过程中不发挥特定作用。此外，结果提示dmPFC胆碱能系统在DCD任务所涉及的注意力过程中发挥作用。
