Barshtein G, Bergelson L, Gratton E, Yedgar S
Department of Biochemistry, Hebrew University, Hadassah Medical School, Jerusalem, Israel.
J Basic Clin Physiol Pharmacol. 1996;7(4):321-9. doi: 10.1515/jbcpp.1996.7.4.321.
Application of hydrostatic pressure of several atmospheres (atm), such as that applied in diving or hyperbaric treatment, has been previously shown to induce the release of membrane components into the extracellular medium. As the shape of red blood cells (RBC) is sensitive to membrane composition, this might imply a subsequent change in RBC shape and volume. The present study demonstrates that application of hydrostatic pressure of up to 15 atm changes the shape of RBC from the normal discoids to stomatocytes (cup-shaped) and accordingly increases their volume. Changes in RBC shape and volume are known to impair physiological and cellular function. Thus, these changes might be pertinent to hemodynamic and physiological disorders observed in humans subjected to elevated pressure.
几个大气压（atm）的静水压力应用，比如潜水或高压治疗中所施加的压力，先前已被证明会促使膜成分释放到细胞外介质中。由于红细胞（RBC）的形状对膜组成敏感，这可能意味着红细胞的形状和体积随后会发生变化。本研究表明，施加高达15个大气压的静水压力会使红细胞的形状从正常的盘状变为口形细胞（杯状），并相应增加其体积。已知红细胞形状和体积的变化会损害生理和细胞功能。因此，这些变化可能与在承受高压的人类中观察到的血液动力学和生理紊乱有关。
