Kaido T L, Veale D J, Havlik I, Rama D B
Department of Experimental and Clinical Pharmacology, University of the Witwatersrand, Johannesburg, South Africa.
J Ethnopharmacol. 1997 Feb;55(3):185-91. doi: 10.1016/s0378-8741(96)01499-7.
Agapanthus africanus, Pentanisia prunelloides and Gunnera perpensa are indigenous plants which are used in traditional herbal remedies during pregnancy and childbirth. A crude decoction of each plant was tested on isolated rat uterus and ileum for pharmacological activity. Agapanthus africanus and Pentanisia prunelloides exhibited direct smooth muscle activity on the uterus and ileum preparations, while Gunnera perpensa showed direct smooth muscle activity on the uterus only. All the plant extracts potentiated the initial response of the uterus to oxytocin but Pentanisia prunelloides reduced the maximum response of the uterus to oxytocin. The Agapanthus africanus and Pentanisia prunelloides extracts potentiated the initial response of the ileum to acetylcholine but all the plant extracts inhibited the maximum response of the ileum to acetycholine.
百子莲、矮桃草和垂花水龙骨是当地植物，在孕期和分娩期间被用于传统草药疗法。分别对这三种植物的粗煎剂进行了离体大鼠子宫和回肠的药理活性测试。百子莲和矮桃草对子宫和回肠制剂表现出直接的平滑肌活性，而垂花水龙骨仅对子宫表现出直接的平滑肌活性。所有植物提取物均增强了子宫对催产素的初始反应，但矮桃草降低了子宫对催产素的最大反应。百子莲和矮桃草提取物增强了回肠对乙酰胆碱的初始反应，但所有植物提取物均抑制了回肠对乙酰胆碱的最大反应。
