Tsai C C, Kao C T, Hsu C T, Lin C C, Lin J G
Research Institute of Chinese Medicine, China Medical College, Taichung, Taiwan, R.O.C.
J Ethnopharmacol. 1997 Feb;55(3):213-22. doi: 10.1016/s0378-8741(96)01503-6.
Syh-Mo-Yiin (SMY), Guizhi-Fuling-Wan (GFW), Shieh-Qing-Wan (SQW) and Syh-Nih-Sann (SNS) are four prescriptions of Traditional Chinese Medicine (TCM) used in the remedy of liver trouble in various types. The hepatoprotective effects of water extracts of these four recipes against D-galactosamine (D-GalN) and carbon tetrachloride (CCl4)-induced acute hepatic damage were determined in rats. The results indicated that the serum glutamate-oxalate-transaminase (sGOT) and the serum glutamate-pyruvate-transaminase (sGPT) levels provoked by D-GalN and CCl4 decreased after treatment with these prescriptions of TCM. Histological changes around portal area (D-GalN-induced hepatotoxicity) and central vein (CCl4-induced hepatotoxicity) were simultaneously improved by the treatment with TCM mentioned above.
四逆散（SMY）、桂枝茯苓丸（GFW）、泻青丸（SQW）和四逆散（SNS）是用于治疗各种类型肝病的四种中药方剂。在大鼠中测定了这四种方剂的水提取物对D-半乳糖胺（D-GalN）和四氯化碳（CCl4）诱导的急性肝损伤的保肝作用。结果表明，用这些中药方剂治疗后，由D-GalN和CCl4引起的血清谷氨酸草酰乙酸转氨酶（sGOT）和血清谷氨酸丙酮酸转氨酶（sGPT）水平降低。上述中药治疗同时改善了门静脉周围区域（D-GalN诱导的肝毒性）和中央静脉（CCl4诱导的肝毒性）的组织学变化。
