Adeneye Adejuwon Adewale
Department of Pharmacology, Faculty of Basic Medical Sciences, Lagos State University College of Medicine, PMB 21266, Ikeja, Lagos, Nigeria.
Afr J Tradit Complement Altern Med. 2009 Mar 7;6(2):131-8.
The hepatoprotective activities and the mechanisms of actions of Musanga cecropioides stem bark aqueous extract (MCW) were investigated on acute hepatocellular injuries induced by intraperitoneal (IP) carbon tetrachloride (CCl(4)) (20% CCl(4)/olive oil, 1.5 mL/kg) and 800 mg/kg/IP of acetaminophen (APAP) in normal saline, in male Wistar rats. Among the Yorubas (South-West Nigeria), cold decoction of MCW is used as a natural antidote for oral gastric poisonings, infective hepatitis and other liver diseases. Its hepatoprotective activities were monitored by assaying for the serum aminotransferases, ornithine carbamoyl transferase and the toxicant-induced histopathological lesions in rat livers 24 hours post-induction. These enzymes are markers of acute hepatic injuries and their elevations are indications of acute liver injuries. Pretreatment of rats with graded doses (125 - 500 mg/kg) of MCW significantly attenuated the acute elevation of the liver enzymes and the hepatotoxin-induced histopathological lesions in the rat livers. The presence of two active natural antioxidants (flavonoids and alkaloids) in high concentrations in MCW may account for the hepatoprotective activities observed in this study. These results, thus, support the folkloric use of MCW for treatment of hepatic injuries resulting from acute gastric poisonings, infective hepatitis or other liver diseases.
在雄性Wistar大鼠中，研究了白颜树茎皮水提取物（MCW）对腹腔注射（IP）四氯化碳（CCl₄）（20% CCl₄/橄榄油，1.5 mL/kg）和800 mg/kg/IP对乙酰氨基酚（APAP）于生理盐水中诱导的急性肝细胞损伤的保肝活性及其作用机制。在约鲁巴人（尼日利亚西南部）中，MCW的冷煎剂被用作口服胃中毒、感染性肝炎和其他肝脏疾病的天然解毒剂。通过在诱导后24小时检测大鼠血清转氨酶、鸟氨酸氨甲酰转移酶以及毒物诱导的肝脏组织病理学损伤来监测其保肝活性。这些酶是急性肝损伤的标志物，其升高表明急性肝损伤。用分级剂量（125 - 500 mg/kg）的MCW预处理大鼠可显著减轻肝脏酶的急性升高以及肝毒素诱导的大鼠肝脏组织病理学损伤。MCW中高浓度存在的两种活性天然抗氧化剂（类黄酮和生物碱）可能是本研究中观察到的保肝活性的原因。因此，这些结果支持了MCW在民间用于治疗急性胃中毒、感染性肝炎或其他肝脏疾病所致肝损伤的用途。
