Fu Q G, Mason C R, Flament D, Coltz J D, Ebner T J
Department of Neurosurgery, University of Minnesota, Minneapolis 55455, USA.
Neuroreport. 1997 Jan 20;8(2):523-9. doi: 10.1097/00001756-199701200-00029.
Monkeys performed a multijoint arm-reaching task that systematically varied movement direction and distance. Purkinje cell activity was recorded from 231 task-related cells, and the complex spike discharge was analyzed in relation to distance and direction. The complex spike activity of 123 Purkinje cells changed significantly relative to the background rate. Of these 123, the activity of 85 cells was related to distance and/or direction. The complex spike activity of 54 of these 85 cells fitted a cosine tuning curve for direction, generally at one distance. Using a simple linear regression model, the complex spike activity of 56 cells was significantly correlated with movement distance, usually in one direction. We conclude that the complex spike discharge of Purkinje cells is spatially tuned and strongly related to movement kinematics.
猴子执行了一项多关节手臂伸展任务，该任务系统地改变了运动方向和距离。从231个与任务相关的细胞中记录了浦肯野细胞的活动，并分析了复合动作电位放电与距离和方向的关系。123个浦肯野细胞的复合动作电位活动相对于背景频率有显著变化。在这123个细胞中，85个细胞的活动与距离和/或方向有关。这85个细胞中的54个细胞的复合动作电位活动在一个距离上通常符合方向的余弦调谐曲线。使用简单线性回归模型，56个细胞的复合动作电位活动与运动距离显著相关，通常在一个方向上。我们得出结论，浦肯野细胞的复合动作电位放电在空间上是调谐的，并且与运动运动学密切相关。
