Phelps E A, Hyder F, Blamire A M, Shulman R G
Department of Psychology, Yale University, New Haven, CT 06520, USA.
Neuroreport. 1997 Jan 20;8(2):561-5. doi: 10.1097/00001756-199701200-00036.
Verbal fluency is known to be associated with activity in the left prefrontal cortex. Recent positron emission tomography (PET) results confirmed this finding. In the present study, high resolution functional magnetic resonance imaging (fMRI) was used to further localize activity in the prefrontal cortex related to verbal fluency. Activation was observed in three behavioral tasks: (1) Repeat-subjects repeated words, (2) Opposite-subjects produced the antonym of words, and (3) Generate-subjects generated words beginning with a given letter. When comparing Generate with both Repeat and Opposite, we observed small areas of activation in the left inferior frontal gyrus and anterior cingulate, similar to the centers of mass reported using PET. We also found additional activation around the superior frontal sulcus.
语言流畅性与左侧前额叶皮质的活动有关，这是已知的。最近的正电子发射断层扫描（PET）结果证实了这一发现。在本研究中，使用高分辨率功能磁共振成像（fMRI）进一步定位前额叶皮质中与语言流畅性相关的活动。在三项行为任务中观察到了激活：（1）重复——受试者重复单词；（2）反义词——受试者说出单词的反义词；（3）生成——受试者生成以给定字母开头的单词。将“生成”任务与“重复”和“反义词”任务进行比较时，我们在左侧额下回和前扣带回中观察到了小面积的激活，类似于使用PET报告的质心。我们还在上额沟周围发现了额外的激活。
