Ueda S, Imayama S
Ueda-Setsuko Dermatology Clinic, Fukuoka, Japan.
Arch Dermatol. 1997 Mar;133(3):355-9.
Q-switched laser therapy is known to be highly effective in treating dermal melanocytosis and pigmented epidermal lesions. However, to our knowledge, there are no reports on the effectiveness of laser therapy for congenital nevi. We evaluated the clinical efficacy and side effects of normal-mode ruby laser therapy for congenital pigmented lesions containing abundant melanin.
A normal-mode ruby laser (pulse duration, 0.3-1.0 x 10(-3) seconds; energy fluence, 10-30 J/cm2; and spot size, 10 x 10 or 15 x 15 mm) (Toshiba Corp, Tokyo, Japan) was used to treat 3 patients with congenital nevi at intervals of 1 to 4 months. In all 3 cases, the pigmented lesions were significantly reduced almost to the level of the surrounding normal skin after 4 laser treatments. The treated areas were virtually free of scarring, and the skin texture resembled that of the surrounding normal skin. Unsightly hair growth was also reduced.
The normal-mode ruby laser was effective in treating congenital nevi and produced good cosmetic results. The risk of recurrence is unknown, but the 3 patients in our study did not have any recurrences during the 18- to 39-month study period.
调Q激光疗法在治疗皮肤黑素细胞增多症和色素性表皮病变方面已知具有高效性。然而，据我们所知，尚无关于激光疗法治疗先天性痣有效性的报道。我们评估了常规模式红宝石激光疗法对含有丰富黑色素的先天性色素性病变的临床疗效和副作用。
使用常规模式红宝石激光（脉冲持续时间为0.3 - 1.0×10⁻³秒；能量密度为10 - 30 J/cm²；光斑大小为10×10或15×15毫米）（日本东京东芝公司），每隔1至4个月对3例先天性痣患者进行治疗。在所有3例病例中，经过4次激光治疗后，色素性病变显著减轻，几乎降至周围正常皮肤的水平。治疗区域几乎没有瘢痕形成，皮肤质地与周围正常皮肤相似。不雅观的毛发增生也有所减少。
常规模式红宝石激光在治疗先天性痣方面有效，并产生了良好的美容效果。复发风险未知，但我们研究中的3例患者在18至39个月的研究期间均未出现任何复发情况。
