Waldorf H A, Kauvar A N, Geronemus R G
Laser and Skin Surgery Center, New York, USA.
Arch Dermatol. 1996 Mar;132(3):301-4.
The Q-switched ruby laser has been used successfully to treat a variety of benign pigmented lesions. In this study, congenital nevi (diameter, < or = 5 cm) in 18 prepubertal children were treated with the Q-switched ruby laser.
Photographic evaluation revealed an average of 57% clearance of pigmentation in all treated nevi by the fourth treatment session and an average maximum clearance of 76% after approximately eight sessions. Greater than 90% clearance of pigment was attained in five patients. Partial repigmentation was seen in all patients who were followed up after discontinuation of therapy. Findings from histopathologic studies, obtained from one patient, revealed reduction of nevus cells in papillary dermis and upper reticular dermis that correlated with clinical lightening. There was no such reduction in the lower reticular dermis. side effects were limited to transient erythema and hypopigmentation.
The Q-switched ruby laser effectively lightens and may clear pigmentation and eliminate superficial nevus cells from small and medium congenital nevi safely without scarring. However, these results are not permanent. The Q-switched ruby laser may be a viable alternative for providing cosmetic improvement for unresectable lesions, but it should not be considered definitive treatment. Additional studies are needed to address the long-term results of this therapy.
调Q红宝石激光已成功用于治疗多种良性色素沉着病变。在本研究中，对18名青春期前儿童的先天性痣（直径≤5 cm）进行了调Q红宝石激光治疗。
照片评估显示，在第四次治疗后，所有治疗痣的色素沉着平均清除率为57%，在大约八次治疗后平均最大清除率为76%。五名患者的色素清除率超过90%。在停止治疗后接受随访的所有患者中均出现了部分色素再沉着。对一名患者进行的组织病理学研究结果显示，乳头真皮层和网状真皮上层的痣细胞减少，这与临床色素变浅相关。网状真皮下层未见此类减少。副作用仅限于短暂的红斑和色素减退。
调Q红宝石激光可有效减轻并可能清除色素沉着，安全地消除中小先天性痣的浅表痣细胞，且不留疤痕。然而，这些结果并非永久性的。调Q红宝石激光可能是改善不可切除病变外观的一种可行选择，但不应被视为确定性治疗方法。需要进一步研究以探讨该疗法的长期效果。
