Fitzgerald P H, Miethke P, Caseley R T
Clin Genet. 1977 Sep;12(3):155-61. doi: 10.1111/j.1399-0004.1977.tb00918.x.
The karyotype of a 7-month-old child had 46 chromosomes, including five abnormal chromosomes in cultured lymphocytes. G-banding indicated the presence of reciprocal translocation products between chromosomes 1 and 7 and between chromosomes 4 and 15. A probable third translocation involved the same chromosome 4p arm and 12q. All metaphases showed these changes. C-band markers and the presence of reciprocal exchange products indicated that the chromosome changes occurred in the zygote or a post-zygotic cell of the child. The mother developed malignant melanoma while carrying the child but did not receive therapy before its birth. The suggestion is made that an undetected common agent was involved in the aetiology of the mother's tumour and the clastogenic change to the child's chromosomes.
一名7个月大儿童的核型有46条染色体，其中培养的淋巴细胞中有5条异常染色体。G显带显示1号和7号染色体之间以及4号和15号染色体之间存在相互易位产物。可能的第三次易位涉及同一条4号染色体短臂和12号染色体长臂。所有中期相均显示出这些变化。C带标记和相互交换产物的存在表明染色体变化发生在受精卵或该儿童的合子后细胞中。母亲在怀这名儿童时患上了恶性黑色素瘤，但在其出生前未接受治疗。有人提出，一种未被检测到的共同因素参与了母亲肿瘤的病因以及对儿童染色体的致断裂变化。
