[Circadian rhythm of blood pressure in patients with chronic kidney failure in the course of diabetes treated with peritoneal dialysis].

In order to evaluate the disturbances in circadian rhythms of blood pressure in 10 patients with chronic renal failure treated with CAPD, we performed blood pressure monitoring during the two following twenty-four hour periods. 40 healthy young male volunteers were included as a control group. They were divided into two subgroups: men whose parents have or have not hypertension. We used Oxford Medilog ABP equipment. Optimal CAPD parameters were confirmed by calculation Kt/V and pcr. To evaluate circadian rhythms in blood pressure we used Cosinor analysis, and to calculate the day-night blood pressure differences we used Student's t-test. In our study we did not find circadian rhythms of systolic, diastolic and mean arterial pressure in CAPD patients. There were also no statistically significant day-night blood pressure differences. The lack of circadian rhythms in blood pressure and statistically significant day-night differences can be explained in patients as the result of volume expansion and other abnormalities such as the lack of diurnal rhythm in atrial natriuretic peptide, rHuEpo therapy, sympathetic overactivation and others.