细胞毒性配体TRAIL的受体。

The receptor for the cytotoxic ligand TRAIL.

作者信息

Pan G, O'Rourke K, Chinnaiyan A M, Gentz R, Ebner R, Ni J, Dixit V M

机构信息

Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

出版信息

Science. 1997 Apr 4;276(5309):111-3. doi: 10.1126/science.276.5309.111.

DOI:10.1126/science.276.5309.111

PMID:9082980

Abstract

TRAIL (also known as Apo-2L) is a member of the tumor necrosis factor (TNF) ligand family that rapidly induces apoptosis in a variety of transformed cell lines. The human receptor for TRAIL was found to be an undescribed member of the TNF-receptor family (designated death receptor-4, DR4) that contains a cytoplasmic "death domain" capable of engaging the cell suicide apparatus but not the nuclear factor kappa B pathway in the system studied. Unlike Fas, TNFR-1, and DR3, DR4 could not use FADD to transmit the death signal, suggesting the use of distinct proximal signaling machinery. Thus, the DR4-TRAIL axis defines another receptor-ligand pair involved in regulating cell suicide and tissue homeostasis.

摘要

肿瘤坏死因子相关凋亡诱导配体（TRAIL，也称为Apo-2L）是肿瘤坏死因子（TNF）配体家族的成员，可在多种转化细胞系中快速诱导细胞凋亡。人们发现TRAIL的人类受体是TNF受体家族中一个未被描述的成员（命名为死亡受体-4，DR4），其含有一个细胞质“死亡结构域”，在该研究系统中能够启动细胞自杀机制，但不激活核因子κB途径。与Fas、TNFR-1和DR3不同，DR4不能利用FADD传递死亡信号，这表明其使用的是独特的近端信号传导机制。因此，DR4-TRAIL轴定义了另一对参与调节细胞自杀和组织稳态的受体-配体对。