Zheng Zaiyong, Zhu Shuang, Wang Xiaobo, Wu Haoran, Fu Min, Hu Houxiang, Gu Zhanjun, Zhang Chunxiang
Department of Cardiology Key Laboratory of Medical Electrophysiology Ministry of Education, Basic Medicine Research Innovation Center for Cardiometabolic Diseases Ministry of Education, The Affiliated Hospital of Southwest Medical University Southwest Medical University Luzhou 646000 China.
Academician Workstation and Department of Cardiology Affiliated Hospital of North Sichuan Medical College Nanchong 637000 China.
Small Sci. 2025 Feb 20;5(5):2400498. doi: 10.1002/smsc.202400498. eCollection 2025 May.
Nanomaterials have been vastly used in daily life. However, owing to their unique properties, nanomaterials also show potential side effects. Among the various organs affected by nanomaterials, the circulatory system stands out as particularly vulnerable, drawing additional attention to its cardiac toxicity. To address the cardiovascular nanotoxicity and further promote the safe use of nanotechnology, a comprehensive review of the cardiotoxicity induced by nanomaterials is provided. The review begins by identifying the current research trends and hotspots in this field via a bibliometric analysis. Subsequently, based on the objectively obtained research hotspots, the mechanism of cardiovascular nanotoxicity, including exposure route, membrane injury, ion disturbance, oxidative stress, inflammation, and cell death, is reviewed and discussed. Finally, current strategies for the mitigation of nanotoxicity are also proposed. The objective of this review is to assist readers in understanding the mechanism of cardiotoxicity induced by nanomaterials and to facilitate their safe application for human health.
纳米材料已在日常生活中得到广泛应用。然而，由于其独特的性质，纳米材料也显示出潜在的副作用。在受纳米材料影响的各种器官中，循环系统尤为脆弱，这使得其心脏毒性受到更多关注。为了解决心血管纳米毒性问题并进一步促进纳米技术的安全使用，本文对纳米材料引起的心脏毒性进行了全面综述。该综述首先通过文献计量分析确定该领域当前的研究趋势和热点。随后，基于客观获得的研究热点，对心血管纳米毒性的机制进行了综述和讨论，包括暴露途径、膜损伤、离子紊乱、氧化应激、炎症和细胞死亡。最后，还提出了当前减轻纳米毒性的策略。本综述的目的是帮助读者理解纳米材料引起心脏毒性的机制，并促进其在人类健康中的安全应用。
