Cox C F, Sübay R K, Suzuki S, Suzuki S H, Ostro E
Department of Restorative Dentistry, School of Dentistry, UAB Station, Birmingham 35294-0007, USA.
Int J Periodontics Restorative Dent. 1996 Jun;16(3):240-51.
Class V cavities with mechanical exposures were prepared in 178 teeth of seven monkeys to observe the temporal healing of exposed pulps in direct contact with various dental materials, with or without a biologic seal of zinc-oxide eugenol cement against microleakage. Thirty pulps were direct capped as calcium hydroxide controls. The remaining 148 exposures were direct capped, 41 with silicate, 39 with zinc phosphate, 33 with amalgam, and 35 with an auto-cured composite. Sixty-four were restored to their cavosurface margin with their respective material and 84 were sealed to the covosurface margin with zinc-oxide eugenol cement. Tissues were obtained by perfusion fixation at intervals of 35, 21, 14, 10, 5, and 3 days, and then processed and evaluated. The results of this study demonstrated that exposed dental pulps possess an inherent healing capacity, allowing cell reorganization and dentin bridge formation when adequately sealed with zinc-oxide eugenol cement to prevent bacterial microleakage.
在7只猴子的178颗牙齿上制备了伴有机械性露髓的V类洞，以观察与各种牙科材料直接接触的暴露牙髓的愈合过程，无论有无氧化锌丁香酚水门汀生物性封闭剂防止微渗漏。30颗牙髓用氢氧化钙直接盖髓作为对照。其余148处露髓采用直接盖髓，41处用硅酸盐，39处用磷酸锌，33处用汞合金，35处用自凝复合树脂。64颗牙齿用各自的材料恢复到洞缘，84颗牙齿用氧化锌丁香酚水门汀封闭到洞缘。每隔35、21、14、10、5和3天通过灌注固定获取组织，然后进行处理和评估。本研究结果表明，暴露的牙髓具有内在的愈合能力，当用氧化锌丁香酚水门汀充分封闭以防止细菌微渗漏时，可实现细胞重组和牙本质桥形成。
