Sitruk-Ware R, de Lignieres B, Basdevant A, Mauvais-Jarvis P
Maturitas. 1980 Oct;2(3):207-11. doi: 10.1016/0378-5122(80)90005-5.
Seven postmenopausal women have been treated daily with 3 mg oestradiol percutaneously applied upon the skin. Blood samples were drawn at 8-h intervals during a 4-day period and on days 5, 7 and 9 from the beginning of the treatment. Plasma Plasma oestradiol (E2), oestrone (E1), follicle stimulating hormone (FSH) and luteinizing hormone (LH) were determined by radioimmunoassay on these samples. The plasma E2 level was significantly increased in the 12th hour (73 +/- 17 pg/ml) but the maximal plasma concentration was obtained only at the third day of treatment (110 +/- 24 pg/ml). Thereafter the mean plasma concentration was more stable. Increments in E1 was smaller and the plasma E2/E1 ratio was 1.51. Plasma FSH and LH di not change significantly during the course of the treatment. Thus the percutaneous administration of E2 appears to be an effective and safe method of delivering E2 into the circulation, and mimicking the physiologic condition. The advantages of this method are discussed.
七名绝经后女性每日接受经皮皮肤涂抹3毫克雌二醇的治疗。在为期4天的时间里，每隔8小时采集一次血样，并在治疗开始后的第5天、第7天和第9天采集血样。对这些样本采用放射免疫分析法测定血浆雌二醇（E2）、雌酮（E1）、卵泡刺激素（FSH）和黄体生成素（LH）。血浆E2水平在第12小时显著升高（73±17皮克/毫升），但仅在治疗第三天才达到最大血浆浓度（110±24皮克/毫升）。此后，平均血浆浓度更为稳定。E1的升高幅度较小，血浆E2/E1比值为1.51。在治疗过程中，血浆FSH和LH没有显著变化。因此，经皮给予E2似乎是一种将E2输送到循环系统并模拟生理状态的有效且安全的方法。本文讨论了该方法的优点。
