Fiet J, Hermano M, Witte J, Villette J M, Haimart M, Gourmel B, Tabuteau F, Rouffy J, Dreux C
Acta Endocrinol (Copenh). 1982 Sep;101(1):93-7. doi: 10.1530/acta.0.1010093.
We report the effects of sublingual absorption of a single dose (0.5 mg) of oestradiol-17 beta (E2) in 8 post-menopausal women, on plasma E2 and oestrone (E1), urine elimination of total E2 + E1 and on plasma FSH and LH. The results show that sublingual absorption of E2 occurs and that plasma concentrations of E2 obtained (between 133.2 to 320 pmol/l) in this way were higher than those obtained after percutaneous absorption of a single dose (3 mg) of E2. The ratio E1/E2 in plasma is close to that of pre-menopausal women.
我们报告了8名绝经后女性单次舌下吸收0.5毫克17β-雌二醇（E2）对血浆E2和雌酮（E1）、尿中总E2 + E1的排泄以及血浆促卵泡激素（FSH）和促黄体生成素（LH）的影响。结果表明，E2可通过舌下吸收，且通过这种方式获得的血浆E2浓度（133.2至320皮摩尔/升之间）高于单次经皮吸收3毫克E2后获得的浓度。血浆中E1/E2的比值接近绝经前女性。
